Clinical Symptoms of viral hepatitis
preicteric or prodromal phase lasts upto 2 weeks. The varaemia causes the patient
to feel unwell with nausea, vomiting, diarrhea, anorexia, headaches, malaise and
distaste for cigarettes.
Occasionally, tender lymphadenopathy is seen with a transient rash in some cases.
Thereafter the jaundice lessens and in the majority of cases the illness is over
within 3-6 weeks.
are few in the acute phase with a mild flu like illness and a rise in serum transferases.
Less than 20 percent of patients develop jaundice and this is mild and self-limiting.
spectrum of clinical features of chronic hepatitis B is broad, ranging from asymptomatic
infection to debilitating disease or even end stage, fatal hepatic failure.
exacerbations may occur spontaneously, often coinciding with evidence of virologic
reactivation may lead to progressive liver injury and when superimposed on well
established cirrhosis may cause hepatic decompensation.
Occasionally these complications bring the patient to initial clinical attention. Extrahepatic complications of chronic hepatitis B, similar to those seen during the prodromal phase of acute hepatitis B are associated with deposition of circulating hepatitis B, antigen antibody immune complexes.
These include arthralgias and arthritis, which are common and the more rare purpuric cutaneous lesions, immune complex glomerulonephritis and generalized vasculitis.
Clinical features of chronic hepatitis C are similar to those described above for chronic hepatitis B. Generally, fatigue is the most common symptom, jaundice is rare.
Extrahepatic complications of chronic hepatitis C are less common thanthey are in chronic hepatitis B, with the exception of essential mixed cryoglobulinemia.
Laboratory features of chronic hepatitis C are similar to those in patients with chronic hepatitis B but aminotransferase levels tend to fluctuate more and to be lower especially in patients with long standing disease.
An interesting and occasionally confusing finding in patients with chronic hepatitis C is the presence of autoantibodies. Rarely patients with autoimmune chronic active hepatitis and hyperglobulinemia have false positive enzyme immunoassays for anti HCV.
On the other hand a proportion of patients with serologically confirmable chronic hepatitis C have circulating autoantibodies to liver kidney microsomes.
These antibodies are anti-KLM1 as seen in patients with autoimmune chronic active hepatitis type 2 and arre directed against a 33 amino acide sequence of P450 IID6.
The occurrence of anti KLM1 in some patients with chronic hepatitis C may result from the partial sequence homology between the epitope recognized by anti LKM1 and two segments of the HCV polyprotein.
addition the finding of this autoantibody in some patients with chronic hepatitis
C suggests that autoimmunity may be laying a role in the pathogenesis of chronic
in viral hepatatis | Different
types of viral hepatitis | Treatment
process of viral hepatitis | What
are the various Causative organisms in viral hepatitis | How
to treat & prevent viral hepatitis | What
is Prognosis in viral hepatitis | Conceived
your First Baby with Hepatitis C in your Blood? | Got
Diagnosed for Hepatitis C Infection? | The
Difficult Task of Diagnosing Hepatitis C in Aged People | How
to deal with Emotionally Disturbed Hepatitis C Infected Persons
to Handle the Undeterred Hepatitis C Infection Spread |
Know the Multiple Entry Routes of Hepatitis C Infection | How
to Trap and Fix Eluding Hepatitis C Symptoms in a Person | Correlativity
between Hepatitis C and HIV Infection | Varied
Treatment Options for Your Hepatitis C Infection | How
Young Children Play Safe with Hepatitis C Viral Infection |
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